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研究成果

  1. Chou CY, Li ZQ, Huang HC, Hung CH, Weng SL*, and Tzou SC*. Development of an Albumin-Masked mutPD-1Ig as a Tumor Lesion-Selective Immune Checkpoint Inhibitor. 2023. ACS Omega. ( ePublication, https://doi.org/10.1021/acsomega.3c06216 ) (* Correspondence: IF: 4.1)

  2. Lin YW, Lin TT, Chen CH, Wang RH, Lin YH, Tseng TY, Zhuang YJ, Tang SY, Lin YC, Pang JY, Chakravarthy RD, Lin HC, Tzou SC, Chao JI. Enhancing Efficacy of Albumin-Bound Paclitaxel for Human Lung and Colorectal Cancers through Autophagy Receptor Sequestosome 1 (SQSTM1)/p62-Mediated Nanodrug Delivery and Cancer Therapy. ACS Nano. 2023 Oct 10;17(19):19033-19051.

  3. Amer TAM, Palanisamy S, So PB, Vijayaraghavan P, Tzou SC, Lu TT, Lin CH, Wang YM. Sustained Releasable Copper and Zinc Biogenic Ions Co-Assembled in Metal-Organic Frameworks Reinforced Bacterial Eradication and Wound Mitigation in Diabetic Mice. Bioconjugate Chemistry.  2023 Sep 20;34(9):1688-1703.

  4. Chen YJ, Chen M, Cheng TL, Tsai YS, Wang CH, Chen CY, Wu TY, Tzou SC, Wang KH, Cheng JJ, Kao AP, Lin SY, Chuang KH. A non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells. Journal of Biomedical Science. 2023 May 31;30(1):35.

  5. Sun SP, Phang CR, Tzou SC, Chen CM, Ko LW. Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression. Scientific Reports. 2023 May 15;13(1):7861.

  6. Jiang FY, Zhang YZ, Tai YH, Chou CY, Hsieh YC, Chang YC, Huang HC, Li ZQ, Hsieh YC, Chen IJ, Huang BC, Su YC, Lin WW, Lin HC, Chao JI, Yuan SSF, Wang YM, Cheng TL, Tzou SC*. A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis. Inflammation and Regeneration. 2023 Feb 16;43(1):13. (* Correspondence. IF: 10.426)

  7. Vijayaraghavan P, Wang YY, Palanisamy S, Lee LY, Chen YK, Tzou SC, Yuan SSF, Wang YM. Hierarchical ensembles of FeCo metal-organic frameworks reinforced nickel foam as an impedimetric sensor for detection of IL-1RA in human samples. Chemical Engineering Journal. 2023 Feb; 458:141444​. 

  8. Huang HC, Chen YT, Lin HH, Li ZQ, Yang JM*, Tzou SC*. Inhibition of IRAK1 Is an Effective Therapy for Autoimmune Hypophysitis in Mice. Int. J. Mol. Sci. 2022 Nov; 23(23), 14958. (* co-correspondence. IF: 6.208)

  9. Chen YT, Chang YH, Nikhil Pathak, Tzou SC, Luo YC, Hsu YC, Li TN, Lee JY, Chen YC, Huang YW, Yang HJ, Hsu NY, Tsai HP, Chang TY, Hsu SC, Liu PC, Chin YF, Lin WC, Yang CM, Wu HL, Lee CY, Hsu HL, Liu YC, Chu JW, Wang HC, Wang JY, Huang CH, Lin CH, Hsieh PS, Lee Wu YH, Hung YJ, Yang JM*. Methotrexate inhibition of SARS-CoV-2 entry, infection and inflammation revealed by bioinformatics approach and a hamster model. Front Immunol. 2022 Dec 21;13:1080897.

  10. Vadhan A, Yang YF, Wang YM, Chen PY, Tzou SC, Cheng KH, Hu SC, Cheng TL, Wang YY, Yuan SF. Fumarate hydratase inhibits non-small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2. Oncol Lett. 2022 Dec 9;25(1):42

  11. Hsu KC, HuangFu WC, Lin TE, Chao MW, Sung TY, Chen YY, Pan SL, Lee JC, Tzou SC, Sun CM, Yang JM. A site-moiety map and virtual screening approach for discovery of novel 5-LOX inhibitors. Scientific Reports. 2020 Jun 29; 10(1):10510.

  12. Palanisamy S, Chen LF, Tzou SC, Wang YM. Near-infrared templated fluorescent probe for nitroxyl: Selective and sensitive turn-on detection in living cells. Sensors and Actuators B: Chemical. 2020; 310: 127839

  13. Lin YL, Chen CH, Liu YK, Huang TH, Tsai NM, Tzou SC*, Liao KW*. Lipo-PEG-PEI complex as an intracellular transporter for protein therapeutics. Int. J. Nanomedicine. 2019 Feb; 14:1119-1130. (* co-correspondence. IF: 7.033 )

  14. Liu KC, Arivajiagane A, Wu SJ, Tzou SC, Chen CY, Wang YM. Development of a novel thermal-sensitive multifunctional liposome with antibody conjugation to target EGFR-expressing tumors. Nanomedicine. 2019 Jan; 15(1):285-294

  15. Lee CJ, Wang CC, Chen M, Chuang KH, Cheng TL, Jian TY, Wang YM, Huang TH, Liao KW*, Tzou SC*. Development of an inflammatory tissue-selective chimeric TNF receptor. Cytokine. 2019 Jan. 113:340-346. (* co-correspondence)

  16. Chuang YC, Wu HY, Lin YL, Tzou SC, Chuang CH, Jian TY, Chen PR, Chang YC, Lin CH, Huang TH, Wang CC, Chan YL, Liao KW. Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer. Biol Proced Online. 2018 May 1;20:10. 

  17. Chen IJ, Chuang CH, Hsieh YC, Lu YC, Lin WW, Huang CC, Cheng TC, Chen YA, Cheng KW, Wang YT, Chen FM, Cheng TL*, Tzou SC*.  Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains. Scientific Reports. 2017 Sep 14; 7(1):11587.  (* co-correspondence)

  18. Lin HH, Gutenberg A, Chen TY, Tsai NM, Lee CJ, Cheng YC, Chen WH, Tzou YM, Caturegli P*, Tzou SC*.  In situ activation of pituitary-infiltrating T lymphocytes in autoimmune hypophysitis. Scientific Reports.  2017 Mar 6; 7: 43492.  (* co-correspondence)

  19. Palanisamy S, Wu PY, Wu SC, Chen YJ, Tzou SC, Wang CH, Wang YM.  In vitro and in vivo imaging of peroxynitrite by a ratiometric boronate-based fluorescent probe. Biosens Bioelectron. 2017 May 15; 91:849-856.

  20. Lin CM, Lin YL, Ho SY, Chen PR, Tsai YH, Chung CH, Hwang CH, Tsai NM, Tzou SC, Ke CY, Chang J, Chan YL, Wang YS, Chi KH, Liao KW. The inhibitory effect of 7, 7"-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization. Oncotarget. 2016 Jul 30; 8(36):60046-60059

  21. Chuang CH, Cheng TC, Leu YL, Chuang KH, Tzou SC, Chen CS. Discovery of Akt kinase inhibitors through structure-based virtual screening and their evaluation as potential anticancer agents. Int J Mol Sci. 2015 Feb 2; 16(2):3202-12.

  22. De Remigis A, de Gruijl TD, Uram JN, Tzou SC, Iwama S, Talor MV, Armstrong TD, Santegoets SJ, Slovin SF, Zheng L, Laheru DA, Jaffee EM, Gerritsen WR, van den Eertwegh AJ, Le DT, Caturegli P. Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival. Int J Cancer. 2015 Jan 1;136(1):127-37.

  23. Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC, Chuang CH, Hsieh YC, Tai MH, Cheng TL. Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system. PLoS One. 2014 May 13;9(5):e97367.

  24. Chuang YC, Lin CJ, Lo SF, Wang JL, Tzou SC, Yuan SS, Wang YM.Dual functional AuNRs@MnMEIOs nanoclusters for magnetic resonance imaging and photothermal therapy. Biomaterials. 2014 May;35(16):4678-87.

  25. Chen YJ, Wu SC, Chen CY, Tzou SC, Cheng TL, Huang YF, Yuan SS, Wang YM. Peptide-based MRI contrast agent and near-infrared fluorescent probe for intratumoral legumain detection. Biomaterials. 2014 Jan;35(1):304-15.

  26. Cheng TC, Chuang KH, Chen M, Wang HE, Tzou SC, Su YC, Chuang CH, Kao CH, Chen BM, Chang LS, Roffler SR, Cheng TL. Sensitivity of PEGylated Interferon Detection by Anti-Polyethylene Glycol (PEG) Antibodies Depends on PEG Length. Bioconjug Chem. 2013 Aug 5. [Epub ahead of print]

  27. Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S, Cheng TL. Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs. Cancer Gene Ther.2013 May;20(5):276-81.

  28. Wu SC, Lin KL, Wang TP, Tzou SC, Singh G, Chen MH, Cheng TL, Chen CY, Liu GC, Lee TW, Hu SH, Wang YM. Imaging specificity of MR-optical imaging agents following the masking of surface charge by poly(ethylene glycol). Biomaterials. 2013 May;34(16):4118-27. 

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